Question for my Twitter-in' peeps

What's the best third-party application/front end thingy to use with Twitter?

I'm beginning to use my own Twitter account a lot more, including photos and probably video as well. It would also be nice to have something that would, if at all possible, automatically aggregate tweets/twits/whatever addressed to me so that I see 'em without having to just happen upon them.

So what would y'all recommend? :-)